Identification and Fine Mapping of a Major QTL,TT1-2, That Plays Significant Roles in Regulating Heat Tolerance in Rice

Plant Molecular Biology Reporter - Global warming threatens many aspects of human life, including a reduction in crop yields, and breeding heat-tolerant crops is a fundamental way to help address...     

Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis

1. Download : Download high-res image (195KB)
2. Download : Download full-size image

     

Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo

1. Download : Download high-res image (127KB)
2. Download : Download full-size image

     

Bifidobacteria-mediated immune system imprinting early in life

1. Download : Download high-res image (173KB)
2. Download : Download full-size image

     

Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

1. Download : Download high-res image (292KB)
2. Download : Download full-size image

     

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

1. Download : Download high-res image (149KB)
2. Download : Download full-size image

     

Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis

This study aims to explore the potential mechanisms of Xinnaokang in atherosclerosis treatment. Firstly, the active components of Xinnaokang were analysed by HPLC, which contains ginsenoside Rg1, puerarin, tanshinone, notoginsenoside R1, ammonium glycyrrhizate and glycyrrhizin. Network pharmacology analysis showed there were 145 common targets of Xinnaokang, including the chemical stress, lipid metabolite, lipopolysaccharide, molecules of bacterial origin, nuclear receptor and fluid shear stress pathways. Then, the animal experiment showed that Xinnaokang reduced the body weight and blood lipid levels of atherosclerotic mice. Vascular plaque formation was increased in atherosclerotic mice, which was markedly reversed by Xinnaokang. In addition, Xinnaokang reduced CAV-1 expression and increased ABCA1, SREBP-1 and LXR expressions in the vasculature. Xinnaokang promoted SREBP-2 and LDLR expressions in the liver but decreased IDOL and PCSK9 expressions, indicating that Xinnaokang regulated lipid transport-related protein expression. Cecal microbiota diversity was reduced in atherosclerotic mice but increased after Xinnaokang treatment. Xinnaokang treatment also improved gut microbiota communities by enriching Actinobacteria, Bifidobacteriales and Bifidobacteriaceae abundances. Metabolic profile showed that Xinnaokang significantly reduced homogentisate, phenylacetylglycine, alanine and methionine expressions in the liver of atherosclerotic mice. Xinnaokang effectively alleviated atherosclerosis, and this effect might be linked with the altered features of the liver metabolite profiles and cecal microbiota.     

Construction of a rAAV-SaCas9 system expressing eGFP and its application to improve muscle mass

Biotechnology Letters - An ideal rAAV gene editing system not only effectively edits genes at specific site, but also prevents the spread of the virus from occurring off-target or carcinogenic...